Viagra on empty stomach did not work!

[faronpats]

Ok so I decided to starve myself on Thursday because I knew a girlfriend of mine was coming over for a movie. Took 50mg Viagra before she got there and I thought it would work in under 30 minutes. To my surprise it did not! We watched a movie and half way through I decided to eat a sandwich and some chips, about 10 minutes after I started feeling the effects and then the Viagra kicked in and worked?

Why is this? I thought that Viagra on an empty stomach is the way it works best and it has before for me but this time I had to eat some food to jump start it? Does anyone have any ideas why this is?

Faron.

[Willie]

Faronpats, one urologist told me that it is safe to take 1.5 times the max dose. I tried this last time I had sex with Levitra, and it really worked. We were able to have sex three times in one night. The only problem was I did get a headache, but it was completely worth it.

Give it a shot if you have enough pills.

[Flavio]

Ok so I decided to starve myself on Thursday because I knew a girlfriend of mine was coming over for a movie. Took 50mg Viagra before she got there and I thought it would work in under 30 minutes. To my surprise it did not! We watched a movie and half way through I decided to eat a sandwich and some chips, about 10 minutes after I started feeling the effects and then the Viagra kicked in and worked?

Why is this? I thought that Viagra on an empty stomach is the way it works best and it has before for me but this time I had to eat some food to jump start it? Does anyone have any ideas why this is?

Faron.

Viagra and all other PDE-5 inhibitors should be taken on an empty stomach. I don't think it was the food that did it in your case. Sometimes it may take a little longer for the effect to kick in. I always take my Cialis two hours before sex, just to make sure. Vigamed (oral phentolamine) works much faster, you only have to wait 15-30 minutes.

[Flavio]

Viagra and all other PDE-5 inhibitors should be taken on an empty stomach. I don't think it was the food that did it in your case. [...]

Faronpats: I think I might be wrong here. The official theory is 'don't eat anything and take Viagra on an empty stomach'. But some EDG users have said that a light meal may actually help digestion and speed things up. Next time, I'll take Cialis with some juice or a light snack.

One thing's for sure: don't take these drugs after a fatty meal.

[erik]

Yeah that's what happened to me as well, flavio is 100% right. Take it on an empty stomach and if it does not work then eat a light snack. If you eat a cheeseburger and then take a viagra it is not going to work that well...

[Flavio]

Here's a recent syudy on food and a new PDE-5 inhibitor called udenafil:



"Effect of food on the pharmacokinetics of the oral phosphodiesterase 5 inhibitor udenafil for the treatment of erectile dysfunction - Abstract


Tuesday, 22 September 2009
Department of Pharmacology and Clinical Pharmacology, Seoul National University College of Medicine and Hospital, Daejeon, Korea.

Udenafil is a cyclic guanosine 3',5'-monophosphate-specific phosphodiesterase type 5 (PDE5) inhibitor developed for the treatment of erectile dysfunction. The aim was to evaluate the effect of food on the pharmacokinetics of udenafil.

An open, randomized, three-way crossover study was conducted. Fifteen healthy male volunteers received a single 200-mg oral dose of udenafil while fasting, after a low-fat meal, and after a high-fat meal separated by 7-day washout periods. Serial blood samples were taken up to 48 h after oral administration.

Under fasting conditions, udenafil was rapidly absorbed and t(max) was observed typically 1.5 h after administration. The mean t(max) values after a low-fat meal and a high-fat meal were 2.6 and 2.1 h, respectively. The ratios (90% confidence intervals) of the geometric means compared with the fasting condition for C(max) and AUC(last) were 0.79 (0.70, 0.90) and 0.96 (0.89, 1.03) in the low fat-fed condition, respectively, and 1.01 (0.89, 1.15) and 1.03 (0.96, 1.11), respectively, in the high fat-fed condition.

The t(max) of udenafil was delayed under the fed conditions. However, although the C(max) was reduced by approximately 21% in the low fat-fed state, overall bioavailability was not affected when taken with food.

Written by:
Kim TE, Kim BH, Kim JR, Lim KS, Hong JH, Kim KP, Kim HS, Shin SG, Jang IJ, Yu KS. Are you the author?

Reference:
Br J Clin Pharmacol. 2009 Jul;68(1):43-6.
doi:10.1111/j.1365-2125.2009.03404.x

PubMed Abstract
PMID:19660002

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