Vigamed - not my choice
Well, I know Flavio swears by this stuff, however its not for everyone. After reading a few posts on this site, I decided to order some from Brazil. When I took it, it was a dreadful experience. I felt my head would explode - I went the colour of beetroot, all my veins bulged, and my heart was racing so quickly I thought I may need medical treatment. I was meeting a girl, and had to cancel at the last moment. I would say these side effects must be fairly common as it didnt get an FDA.
I'm a bit surprised to hear this but everyone is different and reactions to these drugs vary a lot. So yes, it is perfectly possible that some men don't respond well to it. (same thing with Viagra, over 40% of patients don't respond to it)
I'm not an expert and I'm not defending Vigamed here, but there are several studies that show its efficacy and safety:
'Long-term safety and efficacy of oral phentolamine mesylate (Vasomax) in men with mild to moderate erectile dysfunction
The objectives of this study were to evaluate long-term safety and efficacy of phentolamine mesylate, an orally active, rapid-acting alpha-adrenergic receptor antagonist, for the treatment of men suffering from erectile dysfunction (ED). It was an open-label study involving more than 2000 patients. Men received phentolamine mesylate 40 mg or 80 mg (10 tablets/month) as needed for up to 13 months and self-assessed erectile performance using two validated questionnaires. Treatment with phentolamine mesylate was associated with increases in Erectile Function Domain score of the IIEF, successful vaginal penetrations, and in overall satisfaction. Most adverse events were mild or moderate in severity and consistent with the known pharmacodynamic properties of phentolamine. In conclusion, phentolamine mesylate is safe and effective in the long-term treatment of men with mild to moderate ED.
International Journal of Impotence Research (2002) 14, 266-270. doi:10.1038/sj.ijir.3900885
Long-term safety and efficacy of oral phentolamine mesylate (Vasomax) in men with mild to moderate erectile dysfunction
I'm not sure why this wasn't approved by the FDA. Apparently, Vasomax was being developped by a shady company called Zonagen (that later changed its name to Repros Therapeutics) and maybe these guys screwed things up, I don't know. One thing's for sure, though: Zonagen didn't create anything, they simply took an already existing generic drug and renamed it.
Phentolamine is not a new drug and it has been widely used to treat several conditions.
One of the ingredients of the famous trimix-gel for the treatment of ED is phentolamine.
And, like I said, oral phentolamine is a licensed ED treatment in Mexico (under the brand name Z-Max) and Brazil (Vigamed). So, this is not some new experimental drug that no one has ever heard of, it is an approved med.
Vigamed is manufactured by a big pharma company called Cimed Pharmaceuticals. For more on this company and Vigamed, check out their official website: Grupo Cimed - Linha FARMA
Here's a study on phentolamine, its history, uses and possible side effects:
Oral phentolamine (Vasomax(R))
Vasomax(R) is an oral preparation of phentolamine mesilate (Zonagen Pharmaceuticals) currently undergoing worldwide regulatory approval for distribution. Phentolamine is primarily an alpha-adrenergic antagonist with mild sympatholytic action and a beta-adrenergic stimulating action. Over 30 years of clinical experience has shown it to be a strong direct vasodilator on muscular walled vessels, likely based on its inhibitory action on adenosine 5-triphosphate-sensitive potassium channels. This medication is not new, having been marketed in the United States in an oral formulation between 1952 and 1984. Phentolamine initially achieved FDA approval for preoperative use in patients with pheochromocytoma for control of blood pressure and paroxysmal hypertensive episodes. In the past it had been evaluated for hypertension, pulmonary disease, cardiac arrhythmias, angina pectoris and peripheral vascular disease. Unfortunately for most of these indications the clinical responses to oral phentolamine have been variable. The most clinically significant adverse events associated with oral phentolamine in the past were systemic hypotension and vasomotor collapse, severe gastrointestinal side effects especially diarrhea and some complaints of nasal congestion. In this review we will concentrate on phentolamine in a new preparation for on demand treatment of erectile dysfunction of mild to moderate degrees.
Journals on the Web
Like I said, I'm not blindly defending Vigamed here. Yes, there could be side effects and yes, it doesn't work for everyone. So, like I always say, consult your urologist before you decide to try Vigamed or any other drug or natural supplement.
It affects everyone differently, I guess.
The first time I took a Viagra, I felt like all the blood was rushing to my head and when I looked at a regular incandescent bulb it looked like it was putting out bright bright white light instead of a yellowish tint.
Well, I have used pretty much most things - Viagra, Cialis, Levitra and transurethral Muse, all to limited success - with only mild side effects. All - I might also add - have been prescribed by my Doctor. However, as Vigamed is unlicenced, if you want to try it you have to take a punt as no Doc is legally allowed to prescribe it. It should have been a perfect solution for me, given the manner in which it deals with ED.
Originally Posted by Caravan
I guess I was lucky, because I tried all PDE-5 inhibitors (Viagra, Cialis, Levitra) and they were all effective. Cialis is my favourite. Vigamed was also effective and side effects were minimal (nasal congestion, headaches).
On the other hand, cabergoline was totally ineffective - although it seems to work for many men. I also tried a yohimbe supplement, which was terrible: side effects were unbearable (headaches, insomnia, restlessness, tachycardia) and I had to quit.
Originally Posted by jhjl
I guess there are no perfect drugs, they all have potential side effects.
Do you know the nature of your ED problem? Is it psychological? What did your doctor tell you about it? If it is psychogenic, you might want to check Zoraxel, which should be available in a couple of years. I'm convinced that Zoraxel is going to be much better (and safer) than any of the ED drugs that we currently have.
To be honest, dont know what it is now. I'm 50, 20yrs ago diagnosed as hypogonadal - really low testosterone levels. Been on replacement therapy - initially Restandol tablets, now sub-cutaneous implants. My T levels are currently that of a 25 yr old. The only time that things really felt good, was when I first did Viagra late 90's. I had at least four or five years of knowing good erections and having confidence. Then, almost overnight, it wasnt. The Viagra only worked 50% of the time, and then not at all. No reason, I'm told the body doesnt become tolerant. Anyway, I've experimented with loads of combinations, and found cialis 4 hrs prior, then viagra an hour before has limited success. I'm in good shape, dont smoke, I eat very clean, I still train 4 times a week, have good abs and biceps that bust my t-shirt thanks to the testosterone therapy! However, my erections are still difficult to attain. The damndest thing is I get morning glory as hard as you like at least 4/5 mornings a week on waking - so the plumbing is working. My Dr thinks I may have anxiety problems. However - and this is strange - I dont even get erections when I masturbate. I climax at half erection. How can you be anxious on your own?? My blood vessels are fine, I had an EBCT scan which showed my arteries had very little calcium deposits. My blood pressure is sometimes a little high, and it was discovered my adrenaline levels were a little high, but not disasterous enough to treat with medication. So dont really know where it all goes from here to be honest - and neither does my Dr. ...... I do know its not Vigamed though!
If you're wondering "if it's going to work" while you masturbate, that's a stressor too and you may not get totally erect.
DELETED! Sorry Caravan, cannot offer to buy medications on this forum..
Last edited by eduser_admin; 04-13-2010 at 02:00 AM.
Reason: no buying or exchanging
I just got some vigamed after reading some of the posts here. After reading this one, I decided to try half the pill. I experienced no negative effects. I didn't try to get aroused, so I can't judge whether it works or not yet. Next time I'll try a whole pill and add stimulation. Will report results.
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