Bupropion

[Flavio]

We've already mentioned bupropion here and now there's a new study that shows its efficacy in the treatment of SSRI induced ED:


The effects of the adjunctive bupropion on male sexual dysfunction induced by a selective serotonin reuptake inhibitor: A double-blind placebo-controlled and randomized study - Abstract


Monday, 15 February 2010
Urology and Nephrology Research Center, Shahid Beheshti University (MC), Tehran, Iran.

Study Type - Therapy (RCT) Level of Evidence 1b.

To determine the safety and efficacy of adjunctive bupropion sustained-release (SR) on male sexual dysfunction (SD) induced by a selective serotonin reuptake inhibitor (SSRI), as SD is a common side-effect of SSRIs and the most effective treatments have yet to be determined.

The randomized sample consisted of 234 euthymic men who were receiving some type of SSRI. The men were randomly assigned to bupropion SR (150 mg twice daily, 117) or placebo (twice daily, 117) for 12 weeks. Efficacy was evaluated using the Clinical Global Impression-Sexual Function (CGI-SF; the primary outcome measure), the International Index of Erectile Function (IIEF), Arizona Sexual Experience Scale (ASEX), and Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) (secondary outcome measures). Participants were followed biweekly during study period.

After 12 weeks of treatment, the mean (sd) scores for CGI-SF were significantly lower, i.e. better, in patients on bupropion SR, at 2.4 (1.2), than in the placebo group, at 3.9 (1.1) (P= 0.01). Men who received bupropion had a significant increase in the total IIEF score (54.4% vs 1.2%; P= 0.003), and in the five different domains of the IIEF. Total ASEX scores were significantly lower, i.e. better, among men who received bupropion than placebo, at 15.5 (4.3) vs 21.5 (4.7) (P= 0.002). The EDITS scores were 67.4 (10.2) for the bupropion and 36.3 (11.7) for the placebo group (P= 0.001). The ASEX score and CGI-SF score were correlated (P= 0.003). In linear regression analyses the CGI-SF score was not affected significantly by the duration of SD, type of SSRI used and age.

Bupropion is an effective treatment for male SD induced by SSRIs. These results provide empirical support for conducting a further study of bupropion.

Written by:
Safarinejad MR.

Reference:
BJU Int. 2010 Jan 8. Epub ahead of print.
doi:10.1111/j.1464-410X.2009.09154.x

PubMed Abstract
PMID:20067456

UroToday.com Erectile Dysfunction (ED) Section

[Willie]

Flavio, what website do you use for your ED news?

Medicalnewstoday.com is the best I've found, but it's not perfect. It doesn't have all the stuff you find.

[Flavio]

My favorite is this one: UroToday - Home

[Fudgoid]

Interesting study but my guess is its only relevant for those who have been on SSRIs for perhaps a few months at best. I'm on Mirtazapine now and I'll be blown clean over if any med gets me back libido.

I think these studies depend entirely on how badly a person's libido has been effected etc i.e. if you can still think sexual thoughts / have a reasonable desire etc. Somehow my mind has slowly destroyed my desire over 6 months and it went right down the tubes about 3 months ago. Just makes you realise how unstable the mind is. Joke.