The future of ED drugs: my theory

[Flavio]

Gene therapy is going to revolutionise the treatment of ED, but it is still a long way off. Everything is on hold. But the world of medical research doesn’t stop and before gene therapy becomes available, there are going to be new drugs in the market.

I was reading an excellent article (Journal of Andrology, vol. 20, No. 6, November/December 1999) on alpha-adrenergic receptors in the penis and the following words got me thinking:

«If one is to devise an effective therapeutic alternative, then one must reduce adrenergic activity by combining alpha-i- and alpha-2-adrenergic receptor blockade and maximizing enhanced release of NO (Traish et al, 1998). These conclusions suggest that future therapy may employ combination oral drug therapy for the treatment of erectile dysfunction.»

Combination seems to be the key word here. Why should you take two different drugs simultaneously (e.g. Cialis + Vigamed) when you could take only one, risk less side effects and spend half the money? I believe that future Ed drugs will combine the best of two worlds (peripherally acting drugs and centrally acting drugs) in one single pill.

And this is not just a theory. If you do a google search, you’ll find many patent applications such as this one:

COMBINATION THERAPY FOR TREATMENT OF ERECTILE DYSFUNCTION - Patent Application 20010039257

Combination of phentolamine and apomorphine for the treatment of human sexual function and dysfunction - US Patent 6136818 Description

L-arginine and phosphodiesterase (PDE) inhibitor synergism - Patent 6476037

[Flavio]

Here's an interesting article on the subject of combination of different therapies:


International Journal of Impotence Research - Therapeutic strategies for optimizing PDE-5 inhibitor therapy in patients with erectile dysfunction considered difficult or challenging to treat

[Flavio]

And I've just read that several sexual health clinics are currently selling apomorphine + phentolamine lozenges. Combination is the future indeed.

[doofy]

Great article Flavio, thanks for adding it. You mention you know several clinics that already sell apomorphine + phentolamine? Is this the bsoton medical group? Or which clinics sell this?

[Flavio]

Great article Flavio, thanks for adding it. You mention you know several clinics that already sell apomorphine + phentolamine? Is this the bsoton medical group? Or which clinics sell this?

I was thinking of the controversial AMI - Advanced Medical Institute. I've never tried their products, but I believe they sell apomorphine nasal sprays and apomorphine + phentolamine lozenges.

For more on this and a full list of the AMI clinics around the world:

www.avmd.com.au/index.aspx?Action=ClinicList

[tomas]

Flavio, let me know if you go to this clinic. I have read some good tings about them and hear that this nasal spray therapy is even better than injections or viagra. Please let me know..

[erik]

I love your posts Flavio and agree one Gene therapy being the future, but it will be hard for them to break into the ED market. Tomas the AMI clinic is only in Australia and I have never been but have read on a few other forums that their nasal sprays are very effective. I would love to get some more feedback on this myself..

[Flavio]

I love your posts Flavio and agree one Gene therapy being the future, but it will be hard for them to break into the ED market. Tomas the AMI clinic is only in Australia and I have never been but have read on a few other forums that their nasal sprays are very effective. I would love to get some more feedback on this myself..

Hi Erik!

I have been doing more research on those apomorphine nasal sprays and I came across a recent study (2007) by researchers from The University of Shanghai ('Bioavailability of apomorphine hydrochloride released from a nasal spray in rabbits and rats').

They compared the spray with the oral and sublingual forms of the same drug and here's what they had to say about it:

"In recent years, systemic drug delivery via the nasal route has received a lot of attention because it offers a number of advantages including rapid absorption, avoidance of hepatic fi rst-pass metabolism, and the preferential
drug delivery to the brain via the olfactory region [11-14]. Therefore, the nasal delivery of centrally acting APO may provide a better alternative to oral and subcutaneous administration [15-17]."

And their conclusion:

"The higher bioavailability as well as the faster action of APO nasal pray show that it could be an effective treatment of erectile dysfunction"

I'm convinced that the apomorphine nasal sprays sold by Jack Veisman's AMI - Advanced Medical Institute are legitimate and effective. There are studies that back it up and over 300,000 happy customers can't all be wrong. And apomorphine has already been sold in Europe for the treatment of ED - it was called Uprima at the time - so this is not some secret formula they came up with or a complete novelty.

I'm going to London in January 2010 on a business trip and if I have the time, I'll definitely pay a visit to their Harley Street clinic. Yes, their prices are outrageous, but I'm sure it's worth it.

For more on this:

Fastnasaldelivery.com